What question did this study set out to answer?

To assess whether ethnic differences exist in parasympathetic control of cardiac rhythm and respiratory sinus arrhythmia during low and high doses of atropine.

March 1, 1995The Journal of Clinical Pharmacology

The Effect of Atropine on Parasympathetic Control of Respiratory Sinus Arrhythmia in Two Ethnic Groups

View Full Paper

Ask AI

Bookmark

Why the study?

Does ethnicity affect parasympathetic control of respiratory sinus arrhythmia in response to atropine in healthy male volunteers?

Population

18 healthy male volunteers (9 black and 9 white)

Comparison

Incremental cumulative atropine injections of… vs Comparison between black and white ethnic groups

Design

Other

Authors

WPW.J. Du PlooyUniversity of Limpopo CVChris VenterKalafong Hospital

Discussion

Member takes

Implication

Findings do not support ethnicity-based adjustments in parasympathetic assessment; leaves open whether results generalize beyond healthy male volunteers.

Key Points

To assess whether ethnic differences exist in parasympathetic control of cardiac rhythm and respiratory sinus arrhythmia during low and high doses of atropine.
Assessed 18 healthy male volunteers (9 Black, 9 White) using ECG recordings to measure the standard deviation of R-R intervals during deep breathing and drug administration.
Administered incremental cumulative atropine injections (0.001 mg/kg up to 0.005 mg/kg, followed by 0.01 mg/kg and 0.015 mg/kg) alongside standardized respiratory maneuvers.
No significant differences were detected between ethnic groups for any measured cardiac parameter at any stage.
R-R interval variation increased threefold during voluntarily induced respiratory sinus arrhythmia in both groups, an effect completely blocked by 0.01 mg/kg atropine.
A significant inverse quadratic relationship was observed between parasympathetic control and heart rate change (R = .984 for White participants, R = .905 for Black participants).

Structured PICO

Does ethnicity affect parasympathetic control of respiratory sinus arrhythmia in response to atropine in healthy male volunteers?

Population

18 healthy male volunteers (9 black and 9 white)

Intervention

Incremental cumulative atropine injections of 0.001 mg/kg until 0.005 mg/kg, followed by two injections of 0.01 mg/kg and 0.015 mg/kg

Comparator

Comparison between black and white ethnic groups

Outcome

Parasympathetic control of cardiac rhythm measured by standard deviation of the R-R interval during respiratory sinus arrhythmiasurrogate

Ethnicity does not appear to affect parasympathetic control of cardiac rhythm as measured by respiratory sinus arrhythmia response to atropine.

Cite This Study

Plooy et al. (1995) studied this question.

synapsesocial.com/papers/6a7565f9e2936089dd033d20 https://doi.org/10.1002/j.1552-4604.1995.tb04054.x

View Full Paper

Ask AI

Bookmark

Implication

Findings do not support ethnicity-based adjustments in parasympathetic assessment; leaves open whether results generalize beyond healthy male volunteers.

The Effect of Atropine on Parasympathetic Control of Respiratory Sinus Arrhythmia in Two Ethnic Groups

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Effect of Atropine on Parasympathetic Control of Respiratory Sinus Arrhythmia in Two Ethnic Groups

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider