Key result
Intravenous atropine modulates central autonomic outflow by shifting high- and low-frequency sympathetic oscillations.
Why the study?
The effects of central parasympathetic activation on sympathetic nerve activity oscillations are not known.
Does atropine modulate the spectral oscillations of sympathetic nerve activity?
Comparison
Low-dose (2 microgram/kg IV) and high-dose (15 microgram/kg IV) atropine vs baseline
Design
Power spectral analysis study of RR interval, blood pressure, respiration, and MSNA variability
Authors
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Central vagal activation may modulate sympathetic oscillations; leaves open effects on clinical autonomic therapies or outcomes.
Does atropine modulate the spectral oscillations of sympathetic nerve activity?
p-value: p=<0.01
Central parasympathetic activation by atropine modulates the oscillatory characteristics of sympathetic nerve traffic to peripheral blood vessels.
Montano et al. (1998) studied this question. Atropine was evaluated on Spectral oscillations of RR interval and muscle sympathetic nerve activity (MSNA) (p=<0.01). Intravenous atropine at low and high doses increased high-frequency and decreased low-frequency oscillations of muscle sympathetic nerve activity (P<0.02), indicating central parasympathetic modulation.
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