February 1, 1977AJP Heart and Circulatory Physiology

Opposing central and peripheral effects of atropine on parasympathetic cardiac control

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Why the study?

Does atropine affect cardiac vagal efferent activity and heart rate in anesthetized dogs?

Population

Chloralose-urethane-anesthetized dogs weighing an average of 14.6 kg

Design

Preclinical

Authors

PKP. G. Katona DLD. LipsonMassachusetts General Hospital PDPaul J. DauchotCentre Hospitalier Universitaire de Saint-Étienne

Discussion

Member takes

Implication

Reveals dual central-peripheral atropine actions in dogs; leaves open translation to human vagal modulation.

Structured PICO

Does atropine affect cardiac vagal efferent activity and heart rate in anesthetized dogs?

Population

Chloralose-urethane-anesthetized dogs weighing an average of 14.6 kg

Intervention

Atropine sulfate in doses of 0.003-1.5 mg

Outcome

Cardiac vagal efferent (CVE) activity and heart period changessurrogate

Atropine exerts a powerful central stimulating effect on cardiac vagal efferent activity while simultaneously blocking vagal heart rate effects at the periphery in dogs.

Cite This Study

Katona et al. (1977) studied this question.

synapsesocial.com/papers/6a80adf42ea91e47663d6f5d https://doi.org/10.1152/ajpheart.1977.232.2.h146

View Full Paper

Ask AI

Bookmark

Opposing central and peripheral effects of atropine on parasympathetic cardiac control

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Opposing central and peripheral effects of atropine on parasympathetic cardiac control

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider