Why the study?
Does a large intramuscular dose of atropine affect cardiac rhythm in healthy adult male volunteers?
Does a large intramuscular dose of atropine affect cardiac rhythm in healthy adult male volunteers?
Large intramuscular doses of atropine in healthy adults induce an initial slight increase in sinus rate followed by simple atrioventricular dissociation without significant cardiovascular symptoms.
May induce transient AV dissociation after large IM atropine in volunteers; hypothesis-generating and should not change practice.
Atropine sulfate, 175 µg per kilogram, was administered intramuscularly to 6 healthy, adult male volunteers. A continuous electrocardiogram revealed an initial slight increase in sinus rate followed approximately 5 minutes after drug by simple atrioventricular dissociation. This was usually complete with synchronization of atrial and ventricular rates. No significant cardiovascular symptoms were noted.
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Hayes et al. (1971) studied this question.
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