July 1, 1988Clinical CardiologyOpen Access

Comparative cardiac effects of intravenous bolus of ipratropium bromide (itrop) and atropine sulfate in 22 patients

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Why the study?

Does intravenous ipratropium bromide increase heart rate and duration of action compared to atropine sulfate in patients?

Structured PICO

Does intravenous ipratropium bromide increase heart rate and duration of action compared to atropine sulfate in patients?

Population

22 patients evaluated for cardiac effects of vagolytic drugs

Intervention

Ipratropium bromide 0.03 mg/kg intravenous bolus

Comparator

Atropine sulfate 0.03 mg/kg intravenous bolus

Outcome

Maximal heart rate peak and duration of drug actionsurrogate

Intravenous ipratropium bromide produces a more prolonged vagolytic effect on heart rate compared to atropine, suggesting potential utility for vagally mediated conduction disturbances.

Discussion

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Implication

Ipratropium may extend vagolytic coverage in bradycardia; hypothesis-generating for conduction disturbances, pending randomized confirmation.

Cite This Study

Libersa et al. (1988) studied this question.

synapsesocial.com/papers/6a7789adde5e3adfbdf72148 https://doi.org/10.1002/clc.4960110704

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Implication

Ipratropium may extend vagolytic coverage in bradycardia; hypothesis-generating for conduction disturbances, pending randomized confirmation.

Comparative cardiac effects of intravenous bolus of ipratropium bromide (itrop) and atropine sulfate in 22 patients

Structured PICO

Discussion

Implication

Cite This Study

Comparative cardiac effects of intravenous bolus of ipratropium bromide (itrop) and atropine sulfate in 22 patients

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider