Key result
Ischemic and dilated cardiomyopathy show strong PPAR isoform expression without nuclear protein differences versus controls.
Why the study?
The role of PPAR isoforms in regulating energy metabolism in the heart during ischemic and dilated cardiomyopathy conditions was not fully understood.
Case-Control (n=9)
p-value: p=>0.5
PPAR isoforms are strongly expressed in ischemic and dilated cardiomyopathy without changes in nuclear protein turnover, suggesting altered energy metabolism.
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No immediate clinical implications for PPAR targeting in cardiomyopathy; leaves open its role in energy metabolism dysregulation.
Kwabena J. Sarfo (2015) conducted a case-control in Ischemic and dilated cardiomyopathy (n=9). Ischemic and dilated cardiomyopathy vs. Male accident victims (controls) was evaluated on Mean milligram nuclear protein of endocardial tissues (p=>0.5). Ischemic and dilated cardiomyopathy showed strong PPAR isoform expression without significant changes in mean nuclear protein compared to controls (17.6 and 13.7 vs 21.0 mg; P>0.5).
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