Key result
Coronary artery ectasia is not linked to elevated serum copeptin levels versus normal coronary anatomy.
Why the study?
The etiology and pathophysiology of coronary artery ectasia (CAE) have not been fully elucidated, and the relationship between copeptin levels and CAE is unclear.
Are copeptin levels elevated in patients with coronary artery ectasia compared to those with normal coronary arteries?
Observational (n=88)
Are copeptin levels elevated in patients with coronary artery ectasia compared to those with normal coronary arteries?
Copeptin levels do not appear to be elevated in or correlated with coronary artery ectasia, suggesting it may not be a useful biomarker for this condition.
Answers are grounded in this paper and cite their sources.
Copeptin does not appear useful as a biomarker for coronary artery ectasia; hypothesis-generating and should not yet change practice.
Background and aims The etiology and pathophysiology of coronary artery ectasia (CAE) has not been fully elucidated. A rapid rise in plasma copeptin has been observed in cardiovascular diseases, stroke, sepsis, and shock. This increase has diagnostic and prognostic value. The aim of this study was to investigate whether copeptin has a relationship with CAE. Methods This observational prospective study was carried out between October 2012 and March 2013 in the cardiology catheter laboratory with the inclusion of 44 subjects with a diagnosis of CAE and 44 age- and gender-matched individuals with normal coronary arteries. Blood samples obtained from the patients were stored at −70 °C until analysis and copeptin levels in sera were measured by ELISA. Results This study comprised 88 study participants, among whom 44 were patients meeting ectasia criteria [mean age: 58.0 ± 11.5 years; 59% (n = 26) male], and 44 were control subjects with angiographically normal coronary anatomy [mean age: 49.2 ± 10.1 years; 30% (n = 13) male]. Copeptin levels were similar between the groups (p > 0.05). In addition, there was no correlation between copeptin levels and CAE. Conclusion In this study, it is examined that copeptin levels were not elevated in CAE patients.
No takes yet. Share an insight, caveat, or question.
Yavçin et al. (2019) conducted an observational in Coronary artery ectasia (n=88). Coronary artery ectasia vs. Normal coronary arteries was evaluated on Serum copeptin levels (p=> 0.05). Coronary artery ectasia was not associated with elevated serum copeptin levels compared to normal coronary anatomy.
Synapse has enriched 10 related papers. Consider them for comparative context: