Key result
Closed-loop glucose algorithms show no benefit over intensified conventional insulin therapy for normalizing glycemia.
Why the study?
Several algorithms for closed-loop blood glucose regulation have been proposed to replace pancreatic beta cell function in insulin-dependent diabetes, but their comparative effectiveness versus intensified conventional insulin therapy remains unclear.
Do closed-loop blood glucose regulation algorithms improve glycemic control compared to intensified conventional insulin therapy in patients with insulin-dependent diabetes?
Do closed-loop blood glucose regulation algorithms improve glycemic control compared to intensified conventional insulin therapy in patients with insulin-dependent diabetes?
Answers are grounded in this paper and cite their sources.
Closed-loop blood glucose regulation algorithms provide glycemic control comparable to intensified conventional insulin therapy in insulin-dependent diabetes.
Over the past 15 years, several algorithms have been proposed and used for closed-loop blood glucose regulation. Their intent is to artificially replace the normal responses of the pancreatic beta cell absent in insulin-dependent diabetes. All of these algorithms calculate insulin infusion rates on the basis of minute-by-minute measurements of whole blood glucose concentration and its calculated rate of rise or fall. In addition, various techniques are employed to compensate for measurement delay time and the presence of noise in the measured signals. The goal of these feedback systems is to normalize blood glucose in diabetes mellitus. Interestingly, some recently "optimized" versions provide only a near normalization of glycemia in patients with insulin-dependent diabetes, a degree ofglycemic control which is not significantly different from intensified conventional insulin therapy.
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Broekhuyse et al. (1981) conducted a review in Insulin-dependent diabetes mellitus. Closed-loop blood glucose regulation algorithms (Artificial Beta Cell) vs. Intensified conventional insulin therapy was evaluated on Normalization of glycemia. Optimized closed-loop blood glucose regulation algorithms provide near normalization of glycemia, which is not significantly different from intensified conventional insulin therapy.
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