Key result
CABG is linked to improved LV diastolic function, including a ~28% higher E/A ratio.
Why the study?
Investigation and application of methods for improving left ventricular diastolic function in patients with coronary heart disease remain a priority in cardiovascular therapy.
Does coronary artery bypass grafting improve left ventricular diastolic function in patients with coronary heart disease?
Cohort (n=74)
Open-label
No
Does coronary artery bypass grafting improve left ventricular diastolic function in patients with coronary heart disease?
Coronary artery bypass grafting improves left ventricular diastolic function parameters as measured by Doppler echocardiography in patients with coronary heart disease.
Answers are grounded in this paper and cite their sources.
May indicate diastolic benefit from CABG in CHD; hypothesis-generating and requires prospective RCTs before practice change.
UNLABELLED: Diastolic heart dysfunction occurs essentially in patients who suffer from chronic heart failure. In this context an investigation and application of different methods for diastolic function improvement remain a priority in the therapy of cardiovascular diseases. OBJECTIVE: Our ain was to estimate coronary artery bypass grafting effect on the left ventricularfunctionality in patients with coronaty heart disease. METHODS: Patients (30 men without myocardial infarction and 44 - with myocardial infarction) were investigated by Doppler Echocardiography before and after coronary artery bypass grafting for left ventricular diastolic function assessment. In addition, during the year after operation examinations were carried out. Analysis of the data allowed detecting two types of disorders of transmitral flow: rigid and pseudononnal. RESULTS: Our investigation showed that transinitral parameters improved in patients after operation. Patients without myocardial infarction in anamnesis had a myocardium cell relaxation improvement (IVRT decreasing; p =0,046), but an active myocardium relaxation turned for the better (increasing of E/A (p <0,001) by component A lowering (p =0, 003). Changes of pulmonary veins parameters were followed by the improvement of left heart ventricle relaxation: active - PVD decreasing, p =0,051; and passive - PVA decreasing, p =0,028. Patients with myocardial infarction in anamnesis had an IVRT decreasing (p =0,040) and A decreasing (p =0,041). In addition, in this group left atrial function improved (PVS decreasing; p =0,037). CONCLUSION: Coronary artery bypass grafting is effective in left ventricular diastolic function improvement and Doppler Echocardiography method can become an important criterion to estimate the treatment adequacy.
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Хлопина et al. (2015) conducted a cohort in Coronary heart disease with left ventricular diastolic dysfunction (n=74). Coronary artery bypass grafting vs. Baseline (before surgery) was evaluated on Left ventricular diastolic function (E/A ratio in patients without prior myocardial infarction with rigid type dysfunction) (p=<0.001). Coronary artery bypass grafting significantly improved left ventricular diastolic function, including an increase in the E/A ratio and a decrease in isovolumetric relaxation time, in patients with coronary heart disease over 1 year.
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