Key result
Antipsychotic use linked to pulmonary embolism in 4 patients improving after discontinuation and anticoagulation.
Why the study?
Antipsychotic drugs have been reported to increase the risk of pulmonary embolism, but detailed case reports are limited.
Case Report (n=4)
No
Antipsychotic drugs should be considered as a potential contributing factor in patients presenting with otherwise unprovoked pulmonary embolism.
Antipsychotics may contribute to unprovoked PE; hypothesis-generating and requires confirmation in larger studies before practice change.
Pulmonary embolism is the third leading cause of cardiovascular death in the world after stroke and heart attack; several factors have been identified, and it has been reported that antipsychotic drugs increase the risk of pulmonary embolism. It is a brief communication reporting the case of 4 patients under antipsychotic drugs, were hospitalized in the intensive care unit of cardiology in Mohammed VI hospital center for the management of pulmonary embolism. All the etiological investigations performed including SARS COV2 viral serologies with PCR, tumor markers, chest-abdomen-pelvis CT angiogram scan, phthisiology, thrombophilia tests, and lower limbs echo Doppler returned without any notable findings, and the evolution was positive after anticoagulation and stopping antipsychotics.
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Maazouzi et al. (2023) conducted a case report in Pulmonary embolism (n=4). Antipsychotic drugs was evaluated on Clinical evolution. Antipsychotic drugs were identified as the likely contributing factor for pulmonary embolism in 4 patients whose condition improved after stopping the drugs and starting anticoagulation.
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