Antipsychotic medication and venous thrombosis
Why the study?
Does antipsychotic medication increase the risk of venous thrombosis in psychiatric patients?
Population
Psychiatric patients from an autopsy series and patients from the Leiden Thrombophilia Study case-control…
Comparison
Antipsychotic medication vs Control group not using antipsychotic medication
Design
Case-control
Authors
Discussion
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Member takes
Implication
Antipsychotic use was associated with venous thrombosis; leaves open causality and needs prospective confirmation before changing practice.
Structured PICO
Does antipsychotic medication increase the risk of venous thrombosis in psychiatric patients?
P
Population
Psychiatric patients from an autopsy series (n=10 out of 27 deaths from idiopathic pulmonary emboli) and patients from the Leiden Thrombophilia Study (LETS) case-control study
I
Intervention
Antipsychotic medication (including chlorpromazine and its analogues)
C
Comparator
Control group not using antipsychotic medication (in the LETS study)
O
Outcome
Venous thrombosis and fatal pulmonary embolismhard clinical
The use of antipsychotic medication in psychiatric patients appears to be associated with an increased risk of venous thrombosis and fatal pulmonary embolism.
Cite This Study
Thomassen et al. (2001) studied this question.