Key result
Antipsychotic drug use was more frequent in patients with venous thromboembolism compared to controls with arterial hypertension (4.89% vs. 1.82%; OR 2.76; 95% CI 1.01-7.55).
Why the study?
Does the use of antipsychotic drugs increase the risk of venous thromboembolism?
Case-Control (n=540)
No
Does the use of antipsychotic drugs increase the risk of venous thromboembolism?
Odds Ratio: 2.76 (95% CI 1.01–7.55)
Absolute Event Rate: 4.89% vs 1.82%
Antipsychotic drug use is associated with a nearly threefold increased odds of venous thromboembolism, highlighting a potentially fatal adverse effect that requires clinical vigilance.
Antipsychotic use may warrant VTE vigilance in psychiatric care; leaves open causality and generalizability from this case-control design.
Objective. We assessed whether antipsychotic drugs represent a risk factor for venous thromboembolism by comparing the prevalence of antipsychotic drugs use in a population of patients with venous thromboembolism versus a group of individuals treated for hypertension. Methods. We identified 266 patients (141 women) diagnosed as having venous thromboembolism at the average age of 43.1±11 years who had been hospitalized in the University Hospital in Hradec Králové from 1 January 1996 to 31 December 2004. Two hundred and seventy-four patients (140 women) with arterial hypertension, with an average age of 48.3±8.8 years, represented the control population. Results. Use of antipsychotic drugs was moderately more frequent in the group of patients with venous thromboembolism as compared with the control group subjects (4.89 vs. 1.82%; odds ratio 2.76; 95% confidence interval=1.01-7.55). Discussion. We discuss the possible mechanisms of venous thromboembolism induced by antipsychotic agents - hypoactivity, blood status, obesity, abnormal coagulation, autoimmune mechanisms, and hyperhomocysteinemia. Conclusion. Our results indicate the possibility of an increased risk for venous thromboembolism in patients using antipsychotic drugs. It is necessary to seriously consider this possible adverse effect owing to its potentially fatal consequences.
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Masopust et al. (2006) conducted a case-control in Venous thromboembolism (n=540). Antipsychotic drugs vs. Arterial hypertension (control group) was evaluated on Prevalence of antipsychotic drug use (OR 2.76, 95% CI 1.01-7.55). Antipsychotic drug use was more frequent in patients with venous thromboembolism compared to controls with arterial hypertension (4.89% vs. 1.82%; OR 2.76; 95% CI 1.01-7.55).
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