Key result
Antipsychotics, especially low-potency agents, are linked to up to ~13-fold higher VTE risk.
Why the study?
Do antipsychotic medications increase the risk of venous thromboembolism?
Systematic Review
Do antipsychotic medications increase the risk of venous thromboembolism?
Effect estimate: OR 13.3 and 7.1
This review highlights a significant association between antipsychotic medication use, particularly low-potency agents, and an increased risk of venous thromboembolism.
Antipsychotic use may warrant VTE vigilance in at-risk patients; supports association but leaves causal confirmation and practice change open.
OBJECTIVE: This study aims to identify and review available evidence in the literature to determine the strength of association between antipsychotic medications and thromboembolism as an adverse effect. METHOD: Electronic databases were searched for evidence. RESULTS: A total of 15 case reports, 14 case series, two observational studies and three case-control studies were found in the literature. Two case control studies found significantly increased risk of venous thromboembolism (OR 13.3 and 7.1 respectively). The risk was high for low potency antipsychotics. Studies were critically appraised to determine the strength of evidence. CONCLUSION: The studies reviewed indicate a significant association between antipsychotics and venous thromboembolism. Patients using the antipsychotics and those who prescribe them should be aware of this association.
No takes yet. Share an insight, caveat, or question.
Santhana Gunasekaran (2010) conducted a systematic review in venous thromboembolism. Antipsychotic medication was evaluated on venous thromboembolism (OR 13.3 and 7.1). Antipsychotic medication use, particularly low potency agents, was associated with a significantly increased risk of venous thromboembolism (ORs of 13.3 and 7.1 in two case-control studies).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: