Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2009The European Journal of PsychiatryOpen Access

Deep venous thrombosis and pulmonary embolism in psychiatric settings

View Full Paper
Ask AI
Bookmark
Share

Key result

Low-potency antipsychotics, clozapine, and psychiatric immobility are linked to increased VTE risk.

Why the study?

Are psychotropic drugs and specific psychiatric conditions associated with an increased risk of venous thromboembolism in psychiatric patients?

Population

Psychiatric patients

Design

Review

Authors

ENEls G. Van NesteWVWard VerbruggenRode Kruis-VlaanderenMLMark Leysen

Discussion

Loading...

Member takes

Overview

May warrant VTE vigilance in high-risk psychiatric patients; leaves open whether prophylaxis improves outcomes.

Structured PICO

Are psychotropic drugs and specific psychiatric conditions associated with an increased risk of venous thromboembolism in psychiatric patients?

P
Population
A literature review of 12 observational studies, 29 case reports, and 1 review article investigating the risk of venous thromboembolism associated with psychotropic drugs and psychiatric conditions.
E
Exposure
Psychotropic drugs (low potency antipsychotics like chlorpromazine and thioridazine, and clozapine) and psychiatric conditions (physical restraint, catatonia, neuroleptic malignant syndrome)
O
Outcome
Venous thromboembolism (deep venous thrombosis and pulmonary embolism)hard clinical

Low potency antipsychotics and specific psychiatric conditions increase the risk of venous thromboembolism in psychiatric patients, highlighting the need for prophylactic measures.

Limitations

  • Language bias due to exclusion of non-English studies
  • Diagnosis bias as pulmonary embolism is often misdiagnosed as sudden cardiac death
  • Lack of dose information and concomitant medication data in most observational studies
  • Failure to control for other VTE risk factors in retrospective studies and case reports

Cite This Study

Neste et al. (2009) conducted a review in Psychiatric disorders. Psychotropic drugs and psychiatric conditions involving immobility vs. Unexposed psychiatric patients was evaluated on Venous thromboembolism (DVT and PE). Low-potency antipsychotics, clozapine, and psychiatric conditions involving immobility such as physical restraint, catatonia, and neuroleptic malignant syndrome are associated with an increased risk of venous thromboembolism.

synapsesocial.com/papers/6aa50ca09bfc60db011432a0https://doi.org/10.4321/s0213-61632009000100002
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antipsychotic and Antidepressant Drug Use in the Elderly and the Risk of Venous Thromboembolism2002 · 73 citations
  2. 2Risk Factors for Venous Thrombotic Disease1999 · 379 citations
  3. 3Hyperprolactinemia in Patients on Antipsychotic Drugs Causes ADP-Stimulated Platelet Activation That Might Explain the Increased Risk for Venous Thromboembolism: Pilot Study2003 · 59 citations
  4. 4Neuroleptic malignant syndrome: review and analysis of 115 cases1987 · 288 citations