Key result
Idiopathic constipation linked to lower baseline rectal blood flow and blunted reduction after ipratropium.
Why the study?
In functional bowel disorders, it is unknown whether disturbed function is due to intrinsic gut abnormalities or altered extrinsic innervation.
Does inhaled ipratropium affect rectal mucosal blood flow differently in patients with idiopathic constipation compared to healthy volunteers?
Comparison
Inhaled ipratropium 40 microg vs inhaled placebo
Design
Observational study with laser Doppler flowmetry measurements
Authors
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Supports autonomic dysfunction in idiopathic constipation; leaves open whether mucosal flowmetry aids subtyping or management.
Observational (n=98)
Does inhaled ipratropium affect rectal mucosal blood flow differently in patients with idiopathic constipation compared to healthy volunteers?
Laser Doppler mucosal flowmetry demonstrates that patients with idiopathic constipation have impaired extrinsic gut nerve activity, which correlates with the degree of slow transit.
Anton Emmanuel (2000) conducted an observational in Idiopathic constipation (n=98). Idiopathic constipation vs. Healthy volunteers was evaluated on Rectal mucosal blood flow. Idiopathic constipation was associated with lower baseline rectal blood flow and a blunted reduction in blood flow following 40 microg of ipratropium compared to healthy controls.
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