December 3, 2024Neurogastroenterology & MotilityOpen Access

Prospective Evaluation of Autonomic Function and Intestinal Blood Flow in Health and Irritable Bowel Syndrome Shows Differences Limited to Patients With Constipation Predominance

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Why the study?

Previous data on autonomic dysfunction in IBS are conflicting, potentially due to not accounting for bowel patterns or varying methodologies, prompting evaluation of autonomic response across IBS subtypes versus healthy controls.

Does autonomic response differ between IBS subtypes and healthy controls?

Comparison

IBS subtypes vs healthy controls

Design

Prospective cross-sectional physiological study

Authors

YMYoav MazorTel Aviv Sourasky Medical Center MLMargaret M. Leach MJMichael JonesIthaka Harbors

Discussion

Member takes

Implication

Autonomic differences appear limited to IBS-C; leaves open whether subtype-targeted modulation improves symptoms.

Structured PICO

Does autonomic response differ between IBS subtypes and healthy controls?

Population

40 female volunteers (20 with irritable bowel syndrome [IBS] and 20 healthy controls)

Intervention

Comprehensive autonomic testing (fasting and postprandially, cold pressor, and deep breathing challenges)

Comparator

Healthy controls

Outcome

Pulse transit time (PTT) and ultrasound measurements of intestinal blood flowsurrogate

Patients with constipation-predominant IBS display systemic and local autonomic imbalance compared to healthy controls.

Cite This Study

Mazor et al. (2024) studied this question.

synapsesocial.com/papers/6a893e7b75060194fdc977e7 https://doi.org/10.1111/nmo.14975

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Prospective Evaluation of Autonomic Function and Intestinal Blood Flow in Health and Irritable Bowel Syndrome Shows Differences Limited to Patients With Constipation Predominance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prospective Evaluation of Autonomic Function and Intestinal Blood Flow in Health and Irritable Bowel Syndrome Shows Differences Limited to Patients With Constipation Predominance

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider