Key result
Patients with irritable bowel syndrome had significantly less cardiosympathetic and cardiovagal responsiveness to a visceral stressor compared to healthy controls (P=0.001).
Why the study?
Does flexible sigmoidoscopy elicit different autonomic nervous system responses in IBS patients compared to healthy controls?
Population
67 participants including 36 Rome III-positive irritable bowel syndrome patients and 31 healthy controls.
Comparison
Flexible sigmoidoscopy as a visceral stressor. vs Healthy controls undergoing the same procedure.
Design
Case-control
Authors
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Autonomic hyporesponsiveness to visceral stress was associated with IBS; Level 4 evidence leaves open causality and clinical utility.
Case-Control (n=67)
Does flexible sigmoidoscopy elicit different autonomic nervous system responses in IBS patients compared to healthy controls?
p-value: P = 0.001
Irritable bowel syndrome is associated with dysregulated autonomic nervous system responses to visceral stressors, which correlates with disease duration.
Cheng et al. (2013) conducted a case-control in Irritable bowel syndrome (n=67). Irritable bowel syndrome vs. Healthy controls was evaluated on Cardiosympathetic and cardiovagal responsiveness during flexible sigmoidoscopy (p=P = 0.001). Patients with irritable bowel syndrome had significantly less cardiosympathetic and cardiovagal responsiveness to a visceral stressor compared to healthy controls (P=0.001).
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