Key result
Patients with irritable bowel syndrome had a lower median sympathovagal outflow ratio in the standing position (1.4 vs 2.8, p<0.02) and higher during deep breathing (7.33 vs 0.42, p<0.0001).
Why the study?
Do patients with irritable bowel syndrome have altered heart rate variability compared to healthy controls?
Population
53 participants, including 35 patients with irritable bowel syndrome and 18 healthy controls.
Design
Case-control
Authors
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Supports autonomic dysfunction in IBS; leaves open causal direction and therapeutic implications.
Case-Control (n=53)
Do patients with irritable bowel syndrome have altered heart rate variability compared to healthy controls?
Absolute Event Rate: 1.4% vs 2.8%
p-value: p=< 0.02
Patients with irritable bowel syndrome exhibit autonomic dysfunction characterized by reduced sympathetic response to orthostatic stress and diminished parasympathetic modulation during deep breathing.
E Adeyemi (1999) conducted a case-control in Irritable bowel syndrome (n=53). Irritable bowel syndrome vs. Healthy controls was evaluated on Median sympathovagal outflow ratio in the standing position (p=< 0.02). Patients with irritable bowel syndrome had a lower median sympathovagal outflow ratio in the standing position (1.4 vs 2.8, p<0.02) and higher during deep breathing (7.33 vs 0.42, p<0.0001).
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