Key result
Irritable bowel syndrome was associated with a significant reduction in the α index, a marker of cardiac baroreflex, compared to healthy controls (18.1 vs 29 ms/mmHg; p < 0.01).
Why the study?
Does autonomic nervous system function differ between patients with irritable bowel syndrome and healthy controls?
Population
83 subjects: 41 with irritable bowel syndrome classified by Rome III criteria and 42 healthy matched controls.
Design
Case-control
Authors
Loading...
May warrant autonomic evaluation in IBS; leaves open causal links and CV outcome implications.
Case-Control (n=83)
Does autonomic nervous system function differ between patients with irritable bowel syndrome and healthy controls?
Absolute Event Rate: 18.1% vs 29%
p-value: p=< 0.01
Patients with irritable bowel syndrome display significant autonomic nervous system dysregulation, specifically a reduction in cardiac baroreflex, which correlates with stress and somatic symptoms.
Salvioli et al. (2015) conducted a case-control in Irritable bowel syndrome (n=83). Irritable bowel syndrome vs. Healthy matched controls was evaluated on Spontaneous cardiac baroreflex (α index) (p=< 0.01). Irritable bowel syndrome was associated with a significant reduction in the α index, a marker of cardiac baroreflex, compared to healthy controls (18.1 vs 29 ms/mmHg; p < 0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: