Key result
Irritable bowel syndrome in women was associated with significantly impaired heart rate variability, including lower RMSSD (28 vs 38 ms), but not with changes in carotid intima-media thickness or pulse wave velocity.
Why the study?
Does irritable bowel syndrome affect heart rate variability, carotid intima-media thickness, and pulse wave velocity in women?
Cross-Sectional (n=60)
Single-blind (assessor)
No
Does irritable bowel syndrome affect heart rate variability, carotid intima-media thickness, and pulse wave velocity in women?
Irritable bowel syndrome is associated with decreased parasympathetic modulation but does not appear to accelerate subclinical atherosclerosis or arterial stiffness.
IBS may signal autonomic imbalance in women without vascular effects; hypothesis-generating for CV risk, needing prospective confirmation.
OBJECTIVE: Irritable bowel syndrome (IBS), a subgroup of functional somatic disorders, may be associated with autonomic dysfunction (AD). Heart rate variability (HRV), a measure of autonomic dysfunction, may predict survival. The aim of this study was to investigate the effect of IBS on HRV parameters, carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) as surrogates of AD, subclinical atherosclerosis and arterial stiffness, respectively. METHODS: Our study was cross-sectional and observational. Thirty consecutive patients with IBS and 30 control participants underwent 24-hour Holter monitoring, cf-PWV assessment and CIMT measurement. The diagnosis of IBS was based on Rome III criteria. There were 24 patients with IBS-Constipation (80%), 4 patients with IBS-Diarrhea (13.3%), and 2 patients with IBS-Mixed (6.7%) in IBS group. Student t-test and χ2 test were utilized in order to compare continuous and categorical variables between two groups, respectively. RESULTS: Biochemical parameters did not differ between groups except for slightly increased creatinine in patients with IBS. cf-PWV and CIMT values were similar between groups. SDNN index and RMSSD were significantly impaired in patients with IBS compared to controls. Frequency analyses revealed lower LF, HF, and VLF in subjects with IBS. CONCLUSION: We demonstrated decreased parasympathetic modulation in patients with constipation predominant IBS. However, we could not demonstrate any changes in vascular structure and functions measured by carotid intima-media thickness and pulse wave velocity. Our results do not support accelerated atherosclerosis in IBS population.
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Durakoğlugil et al. (2014) conducted a cross-sectional in Irritable bowel syndrome (n=60). Irritable bowel syndrome vs. Healthy controls was evaluated on RMSSD (square root of the mean squared differences of successive NN intervals) (p=0.002). Irritable bowel syndrome in women was associated with significantly impaired heart rate variability, including lower RMSSD (28 vs 38 ms), but not with changes in carotid intima-media thickness or pulse wave velocity.
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