Key result
Higher NT-proBNP linked to ~37% greater risk of in-hospital death in severe COVID-19.
Why the study?
Whether NT-proBNP predicted outcome of patients with severe COVID-19 was unknown.
Does higher NT-proBNP predict in-hospital death in patients with severe COVID-19?
Observational (n=54)
Double-blind data collection
No
Does higher NT-proBNP predict in-hospital death in patients with severe COVID-19?
Hazard Ratio: 1.368 (95% CI 1.217–1.541)
Absolute Event Rate: 60% vs 0%
p-value: p=<0.001
Elevated NT-proBNP (>88.64 pg/mL) serves as an independent prognostic biomarker for in-hospital mortality in patients with severe COVID-19.
May inform prognosis in severe COVID-19; leaves open whether NT-proBNP-guided strategies improve outcomes.
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury was dominate in the process. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of COVID-19 patients was unknown. The study initially enrolled 102 patients with severe COVID-19 pneumonia from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. Results found that patients with higher NT-proBNP (above 88.64 pg/mL) level had more risks of in-hospital death. After adjusting for potential cofounders in separate modes, NT-proBNP presented as an independent risk factor of in-hospital death in patients with severe COVID-19.
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Gao et al. (2020) conducted an observational in Severe COVID-19 pneumonia (n=54). Higher NT-proBNP (>88.64 pg/mL) vs. Lower NT-proBNP (≤88.64 pg/mL) was evaluated on In-hospital death (HR 1.368, 95% CI 1.217-1.541, p=<0.001). Higher NT-proBNP levels (>88.64 pg/mL) were independently associated with an increased risk of in-hospital death in patients with severe COVID-19 (HR 1.368).
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