Key result
T2D duration of 5-10 years is linked to higher syntax and vessel scores versus <5 years.
Why the study?
The study aimed to compare angiographic changes in coronary artery disease severity according to the duration of type 2 diabetes mellitus.
Does the duration of type 2 diabetes mellitus affect the severity of coronary artery disease in patients undergoing coronary angiography?
Cross-Sectional (n=175)
Does the duration of type 2 diabetes mellitus affect the severity of coronary artery disease in patients undergoing coronary angiography?
p-value: p=0.019
Significant structural changes in coronary arteries, including higher syntax and vessel scores, are observed in patients with 5-10 years of type 2 diabetes compared to those with shorter disease duration.
T2DM duration may mark greater CAD complexity; hypothesis-generating and should not yet change practice.
AIM: The aim of our study was to compare the angiographic changes in 53 nondiabetic patients, 54 type 2 diabetic patients of less than 5 years of duration, 41 patients with 5-10 years of diabetes, and 27 with more than 10 years of diabetic duration. METHODS: In this cross-sectional study, 175 patients, who underwent coronary angiogram for the evaluation of the coronary artery disease (CAD), were recruited. Based on the angiographic findings, syntax score, vessel score, and coronary collaterals grading were analyzed. The biochemical analysis was done by using the auto analyzer. RESULTS: A significant increase in the mean syntax score (p=0.019), vessel score (p=0.007), and coronary collateral grade (p=0.008) was observed in the patients with 5-10 years of diabetes when compared to those with less than 5 years of diabetic duration. There was no significant difference in the mean syntax score (p=0.979), vessel score (p=0.299), and collateral grade (p=0.842) between the patients with 5-10 years and more than 10 years of diabetes. The difference in the mean syntax score (p=0.791), vessel score (p=0.098), and collateral grade (p=0.661) between the nondiabetic and the patients with less than 5 years of diabetes was not significant. CONCLUSION: A significant structural change in the coronary arteries was found among the patients with 5-10 years of diabetes.
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Srinivasan et al. (2016) conducted a cross-sectional in Coronary artery disease and type 2 diabetes mellitus (n=175). Type 2 diabetes mellitus duration vs. Nondiabetic patients and other diabetes durations was evaluated on Angiographic changes including syntax score, vessel score, and coronary collaterals grading (p=0.019). Type 2 diabetes duration of 5-10 years was associated with significantly higher mean syntax score (p=0.019), vessel score (p=0.007), and collateral grade (p=0.008) compared to duration <5 years.