Absolute Configuration and Grignard Reaction of Chiral 4-Isopropyl-3-methyloxazolidines

A new chiral 4-isopropyl-3-methyloxazolidines were synthesized by the condensation of N-methylvalinol with some aldehydes.The absolute configuration and asymmetric reactions of these compounds were discussed.The asymmetric heterocyclic compounds play an important role for high stereoselectivity.Recently, the asymmetric reaction with extremely high yield using the chiral oxazolidones derived from (S)-valinol was reported.This investigation suggested that the isopropyl group of optically active (S)-valine produces very high asymmetric induction.Chiral oxazolidine compounds, e .g ., 3.4-dimethyl-5-phenyloxazolidines. 2, pyrrolidino [l, 2-cl oxazolidine ,3) and 4-ethoxycarbonyl-5-phenyloxazolidine4) were known.