Key result
Moderate-to-severe NAFLD linked to ~95% higher odds of abnormal LV relaxation.
Why the study?
The association between non-alcoholic fatty liver disease and left ventricular diastolic dysfunction and remodeling remains equivocal in the general population.
Is non-alcoholic fatty liver disease associated with an increased risk of left ventricular diastolic dysfunction and remodeling in the general population?
Population
20,821 Korean men and women who received health checkup including echocardiography from 2011 to 2012
Comparison
Mild and moderate-to-severe NAFLD vs normal group without NAFLD
Design
Cross-sectional study
Authors
Loading...
May support cardiac evaluation in moderate-severe NAFLD; leaves open causality and need for prospective outcome studies.
Cross-Sectional (n=20,821)
Is non-alcoholic fatty liver disease associated with an increased risk of left ventricular diastolic dysfunction and remodeling in the general population?
Odds Ratio: 1.95 (95% CI 1.61–2.35)
The severity of non-alcoholic fatty liver disease is independently associated with an increased risk of left ventricular diastolic dysfunction and concentric remodeling in the general population.
Jung et al. (2016) conducted a cross-sectional in Non-alcoholic fatty liver disease (n=20,821). Moderate-to-severe non-alcoholic fatty liver disease vs. Normal (no NAFLD) was evaluated on Abnormal LV relaxation (OR 1.95, 95% CI 1.61-2.35). Moderate-to-severe non-alcoholic fatty liver disease was associated with higher odds of abnormal left ventricular relaxation compared to normal controls (OR 1.95; 95% CI 1.61-2.35).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: