Oxidized Phospholipids Predict the Presence and Progression of Carotid and Femoral Atherosclerosis and Symptomatic Cardiovascular Disease
Key result
OxPL/apoB strongly correlates with Lp(a) and predicts carotid and femoral atherosclerosis development.
- n=826
Why the study?
The predictive value of oxidized phospholipids on apoB particles for carotid and femoral atherosclerosis and symptomatic cardiovascular disease was not established.
Population
765 and 671 subjects aged 40-79 years from the Bruneck study in 1995 and 2000
Comparison
OxPL/apoB levels correlated with Lp(a) levels and atherosclerosis presence and progression
Design
Prospective population-based cohort study
Authors
Discussion
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Implication
Prospective cohort study demonstrates that oxidized phospholipids independently predict atherosclerosis progression, indicating their value as predictive biomarkers for cardiovascular disease.
Key Points
- To determine whether circulating levels of oxidized phospholipids predict the presence and prospective progression of carotid and femoral atherosclerosis as well as incident cardiovascular disease.
- Assessed circulating levels of oxidized phospholipids on apolipoprotein B-100 particles in a population-based prospective cohort.
- Evaluated baseline prevalence and 5-year progression of carotid and femoral artery atherosclerosis using high-resolution ultrasound imaging.
- Tracked incident symptomatic cardiovascular disease events across prospective follow-up and adjusted for traditional cardiovascular risk factors.
- Elevated oxidized phospholipid levels showed a significant positive association with the baseline presence and severity of carotid and femoral atherosclerosis.
- Higher circulating oxidized phospholipid concentrations significantly predicted 5-year anatomical progression of vascular plaques across peripheral arterial territories.
- Elevated oxidized phospholipid levels independently predicted increased risk of symptomatic cardiovascular events after multivariable adjustment for standard lipid panels and clinical risk factors.
Study Design
Type
Cohort (n=826)
PICO
P
Population
Prospective population-based survey of 826 men and women aged 40 to 79 years, followed from 1995 to 2000 to assess the predictive value of oxidized phospholipids on atherosclerosis.
E
Exposure / Comparator
Oxidized phospholipids (OxPL/apoB)
O
Primary Outcome
Presence, extent, and development of carotid and femoral atherosclerosis
Cite This Study
Tsimikas et al. (2006) conducted a cohort in Carotid and femoral atherosclerosis (n=826). Oxidized phospholipids (OxPL/apoB) was evaluated on Presence, extent, and development of carotid and femoral atherosclerosis. Oxidized phospholipids (OxPL/apoB) were highly correlated with Lp(a) (r=0.87, p<0.001) and significantly predicted the presence, extent, and development of carotid and femoral atherosclerosis.