Key result
Highest ox-LDL tertile linked to ~23% higher 10-year risk of carotid atherosclerosis progression.
Why the study?
Do higher circulating ox-LDL levels predict the 10-year progression of subclinical carotid atherosclerosis in subjects free of cardiovascular disease?
Cohort (n=804)
Do higher circulating ox-LDL levels predict the 10-year progression of subclinical carotid atherosclerosis in subjects free of cardiovascular disease?
Relative Risk: 1.23 (95% CI 1.07–1.42)
p-value: p=0.003
Higher circulating ox-LDL levels independently predict the 10-year progression of subclinical carotid atherosclerosis, regardless of LDL particle number and size.
AIMS: To investigate the association between circulating oxidized low-density lipoprotein (ox-LDL) levels and progression of subclinical atherosclerosis and to examine whether this link is independent of other low-density lipoprotein (LDL)-related parameters. METHODS: Totally, 804 subjects who were free of cardiovascular disease at baseline completed risk factor surveys and carotid ultrasound measurements in 2002 and 2012. Modified Poisson regression was performed to examine the association between baseline serum ox-LDL levels and the 10-year risk of progression of carotid atherosclerosis which was defined as the development of at least one new plaque in a previously plaque-free carotid segment at re-examination. RESULTS: The mean age of the subjects was 58.6±7.7 years at baseline and 43.3% were men. A total of 504 (62.7%) subjects had carotid plaque progression at re-examination. Subjects in the intermediate and highest tertiles of ox-LDL had a significantly higher adjusted risk of atherosclerosis progression than those in the lowest tertile [relative risk (95% confidence interval) 1.17 (1.01-1.34) for the intermediate tertile and 1.23 (1.07-1.42) for the highest tertile]. This association was independent of baseline levels of LDL-C, total LDL particle number, and small LDL particle number. CONCLUSION: This study demonstrates that serum ox-LDL levels predict 10-year progression of subclinical atherosclerosis. Moreover, this effect is independent of the cholesterol content, the number, and the size of LDL particles.
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Gao et al. (2018) conducted a cohort in Subclinical carotid atherosclerosis (n=804). Circulating oxidized low-density lipoprotein (ox-LDL) vs. Lowest tertile of ox-LDL (<41.0 U/L) was evaluated on 10-year progression of carotid atherosclerosis (development of at least one new plaque in a previously plaque-free carotid segment) (RR 1.23, 95% CI 1.07-1.42, p=0.003). Subjects in the highest tertile of circulating oxidized low-density lipoprotein had a significantly increased 10-year risk of carotid atherosclerosis progression compared to the lowest tertile (RR 1.23).
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