Key result
High non-HDL cholesterol was significantly associated with an increased risk of carotid atherosclerosis in both elderly men (OR 2.990) and women (OR 2.280) compared to the lowest tertile.
Why the study?
Are higher levels of non-HDL cholesterol associated with an increased risk of carotid atherosclerosis in elderly in-patients?
Cross-Sectional (n=921)
No
Are higher levels of non-HDL cholesterol associated with an increased risk of carotid atherosclerosis in elderly in-patients?
Odds Ratio: 2.99 (95% CI 1.651–5.415)
p-value: p=< 0.001
Non-HDL cholesterol levels show a positive and linear relationship with carotid atherosclerosis in the elderly, serving as a potential predictor of risk.
May support non-HDL cholesterol as a risk marker in elderly inpatients; cross-sectional data leaves open causality and needs prospective validation.
The aim of the present study was to evaluate sclerotic lesions of the common carotid artery by ultrasonography in 921 in-patients aged 65 years and older (77 +/- 7 years) and investigate whether lipid levels were associated with carotid atherosclerosis. In men, an increased risk for carotid atherosclerosis was associated with increased levels of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). Compared to men with the lowest tertile of LDL-C levels (< 83.4 mg/dl), the adjusted odds ratio was 2.502 (95% confidence interval: 1.426-4.390) in those with the middle tertile (83.4-115.2 mg/dl), and 2.688 (1.509-4.790) in those with the highest tertile ( > 115.2 mg/dl). Like the LDL-C level, the non-HDL-C level showed a positive and linear relationship with carotid atherosclerosis. Compared to men with the lowest tertile of non-HDL-C levels ( < 101 mg/dl), the adjusted odds ratio was 2.881 (1.633-5.081) for those with the middle tertile (101-135 mg/dl), and 2.990 (1.651-5.415) for those with the highest tertile ( > 135 mg/dl). Similarly, in women, an increased risk for carotid atherosclerosis was also positively and linearly associated with LDL-C and non-HDL-C. The Non-HDL-C level is a potential predictor of risk for carotid atherosclerosis in the elderly.
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Kawamoto et al. (2005) conducted a cross-sectional in Carotid atherosclerosis (n=921). High non-HDL cholesterol vs. Low non-HDL cholesterol was evaluated on Carotid atherosclerosis (IMT ≥ 1.1 mm) in men (highest vs lowest tertile of non-HDL-C) (OR 2.990, 95% CI 1.651-5.415, p=< 0.001). High non-HDL cholesterol was significantly associated with an increased risk of carotid atherosclerosis in both elderly men (OR 2.990) and women (OR 2.280) compared to the lowest tertile.
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