Key result
Higher non-HDL-C/HDL-C ratios were significantly associated with the presence of carotid atherosclerotic plaque in postmenopausal women (OR 1.30; 95% CI 1.07-1.58; p=0.009).
Why the study?
The relationship between the non-HDL-C/HDL-C ratio and the presence of carotid atherosclerotic plaque in postmenopausal women was unknown.
Does a higher non-HDL-C/HDL-C ratio predict the presence of carotid atherosclerotic plaque in postmenopausal women?
Cross-Sectional (n=440)
Does a higher non-HDL-C/HDL-C ratio predict the presence of carotid atherosclerotic plaque in postmenopausal women?
Odds Ratio: 1.3 (95% CI 1.07–1.58)
p-value: p=0.009
The non-HDL-C/HDL-C ratio is a useful surrogate marker for predicting the presence of carotid atherosclerotic plaque in postmenopausal women.
May support non-HDL-C/HDL-C ratio as surrogate for carotid plaque in postmenopausal women; hypothesis-generating and should not yet change practice.
Background: A novel lipid relation, the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) ratio gathers information on all atherogenic and antiatherogenic particles on a single date. The relationship between this lipid marker and the presence of carotid atherosclerotic plaque (CAP) in postmenopausal women is unknown.Methods: Postmenopausal women in primary prevention up to 70 years of age were recruited. Association between the non-HDL-C/HDL-C ratio and presence of CAP, assessed by ultrasonography, was analyzed. Receiver operating characteristic (ROC) curve analysis was performed.Results: A total of 440 females with a mean age of 58.1 ± 5.3 years were recruited. The mean non-HDL-C/HDL ratio was 3.1 ± 1.2 and 28.2% of woman had CAP. A positive relationship was seen between quintiles of the non-HDL-C/HDL-C ratio and prevalence of CAP (p < 0.001). Regardless of other risk factors, women with higher non-HDL-C/HDL-C ratios had a greater chance of having CAP (odds ratio 1.30, 95% confidence interval: 1.07–1.58, p = 0.009). In the ROC curve analysis, the area under the curve of the non-HDL-C/HDL ratio for detecting CAP was 0.703 (95% confidence interval: 0.640–0.765) and the optimal cut-off point was 3.0 (Youden index 0.395).Conclusion: The present study suggests that the non-HDL-C/HDL-C ratio might be a strong marker for predicting the risk of CAP in postmenopausal women.
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Massón et al. (2019) conducted a cross-sectional in Primary prevention (n=440). Higher non-HDL-C/HDL-C ratio was evaluated on Presence of carotid atherosclerotic plaque (CAP) (OR 1.30, 95% CI 1.07-1.58, p=0.009). Higher non-HDL-C/HDL-C ratios were significantly associated with the presence of carotid atherosclerotic plaque in postmenopausal women (OR 1.30; 95% CI 1.07-1.58; p=0.009).
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