Key result
Top-tertile non-HDL-C is linked to ~50% higher odds of asymptomatic vulnerable carotid plaques.
Why the study?
Carotid plaque rupture relates to cerebrovascular disease, and non-HDL-C may be a risk factor, but its association with asymptomatic vulnerable carotid atherosclerotic plaques was unclear.
Are higher non-HDL-C levels associated with an increased prevalence of asymptomatic vulnerable carotid atherosclerotic plaques in individuals not on lipid-lowering therapy?
Cross-Sectional (n=2,888)
Are higher non-HDL-C levels associated with an increased prevalence of asymptomatic vulnerable carotid atherosclerotic plaques in individuals not on lipid-lowering therapy?
Odds Ratio: 1.5 (95% CI 1.23–1.82)
p-value: p=< 0.01
Higher non-HDL-C levels are significantly associated with the presence of asymptomatic vulnerable carotid plaques in individuals not taking lipid-lowering agents.
Non-HDL-C was associated with vulnerable plaques; leaves open whether lowering it reduces cerebrovascular events.
BACKGROUND AND PURPOSE: Carotid atherosclerosis, especially rupture of plaques, is related to cerebrovascular diseases. Non-high-density lipoprotein cholesterol (non-HDL-C) is relevant to cerebrovascular diseases and may be a potential risk factor. We designed this study to investigate the association between non-HDL-C and the prevalence of asymptomatic vulnerable carotid atherosclerotic plaques. METHODS: We enrolled 2888 participants who underwent carotid atherosclerotic plaque detection and non-HDL-C measurement, with no history of taking lipid-lowering agents, from the Asymptomatic Polyvascular Abnormalities in Community study. We used multivariable logistic regression to estimate the association between non-HDL-C levels and the presence of asymptomatic vulnerable carotid atherosclerotic plaques. RESULTS: In our study, 1505 subjects had asymptomatic vulnerable carotid atherosclerotic plaques and 1383 subjects had stable plaques. After adjustment for confounding factors, the odds ratios for vulnerable plaques of non-HDL-C levels in the middle and highest tertile groups were 1.02 (95% confidence interval, 0.84-1.23) and 1.50 (95% confidence interval, 1.23-1.82), respectively (P trend < 0.01). CONCLUSION: In our community-based observational and cross-sectional study, non-HDL-C level was a significant risk factor for the occurrence of asymptomatic vulnerable carotid plaques.
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Wu et al. (2019) conducted a cross-sectional in Asymptomatic vulnerable carotid atherosclerotic plaques (n=2,888). Non-high-density lipoprotein cholesterol (non-HDL-C) levels vs. Lowest tertile of non-HDL-C was evaluated on Presence of asymptomatic vulnerable carotid atherosclerotic plaques (OR 1.50, 95% CI 1.23-1.82, p=< 0.01). Non-HDL-C levels in the highest tertile were significantly associated with the presence of asymptomatic vulnerable carotid atherosclerotic plaques (OR 1.50; 95% CI 1.23-1.82; P trend < 0.01).
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