Key result
Cumulative exposure to non-HDLC burden strongly predicted newly developed carotid plaque, with the highest quartile associated with increased risk versus the lowest (OR 2.74; 95% CI 2.22-3.38).
Why the study?
Atherosclerosis risk is influenced by both magnitude and cumulative lipoprotein exposure, prompting investigation into cumulative exposure to different lipid parameters and the risk of newly developed carotid plaque.
Does cumulative exposure to different lipid parameters predict the risk of newly developed carotid plaque in asymptomatic adults?
Population
2947 participants in the Asymptomatic Polyvascular Abnormalities Community study
Comparison
Cumulative exposure to different lipid parameters across quartiles
Design
Prospective cohort study
Follow-up
Every 2 years from 2006 to 2012
Authors
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May support cumulative lipid tracking for vascular risk; leaves open whether targeting exposure alters plaque incidence.
Cohort (n=2,947)
Does cumulative exposure to different lipid parameters predict the risk of newly developed carotid plaque in asymptomatic adults?
Odds Ratio: 2.74 (95% CI 2.22–3.38)
Wang et al. (2021) conducted a cohort in Atherosclerosis / Carotid plaque (n=2,947). Cumulative exposure to non-HDLC burden vs. Lowest quartile of non-HDLC burden was evaluated on newly developed carotid plaque (OR 2.74, 95% CI 2.22-3.38). Cumulative exposure to non-HDLC burden strongly predicted newly developed carotid plaque, with the highest quartile associated with increased risk versus the lowest (OR 2.74; 95% CI 2.22-3.38).
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