Key result
Compared to the lowest quartile, non-HDL-C in the highest quartile was independently associated with a 1.317-fold increased risk of carotid plaques in normotensive and euglycemic Chinese females.
Why the study?
Does elevated non-HDL-C associate with increased carotid atherosclerosis in normotensive and euglycemic middle-aged and elderly adults?
Cross-Sectional (n=1,470)
No
Does elevated non-HDL-C associate with increased carotid atherosclerosis in normotensive and euglycemic middle-aged and elderly adults?
Non-HDL-C is independently associated with carotid atherosclerosis in normotensive and euglycemic middle-aged and elderly females, suggesting it may be a useful marker for cardiovascular risk assessment even in low-risk populations.
Answers are grounded in this paper and cite their sources.
Non-HDL-C was associated with carotid plaques in low-risk females; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: We investigate whether non-high-density lipoprotein cholesterol (non-HDL-C) provides a better estimate of cardiovascular risk than other lipid profiles in normotensive and euglycemic middle-aged and elderly adults. METHODS: A total of 512 males and 958 females were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima-media thicknesses (CIMTs) were measured using ultrasonography, and the presence of carotid plaques was assessed. RESULTS: The mean values of non-HDL-C were 3.4 ± 0.8 mmol/l and 3.6 ± 0.9 mmol/l for male and female subjects, respectively. Compared with female subjects with non-HDL-C in the first quartile, female subjects with non-HDL-C in the fourth quartile had 1.317-fold increased risks for carotid plaques after adjusting for conventional cardiovascular disease (CVD) risk factors and increasing quartiles of all lipid levels. Non-HDL-C was positively associated with the CIMT after adjusting for CVD risk factors in female subjects (β = 0.062, P = 0.034). CONCLUSIONS: These results suggest that non-HDL-C is independently associated with carotid atherosclerosis in normotensive and euglycemic females.
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Ma et al. (2017) conducted a cross-sectional in Carotid atherosclerosis (n=1,470). Highest quartile of non-HDL-C vs. Lowest quartile of non-HDL-C was evaluated on Presence of carotid plaques (OR 1.317, 95% CI 1.019-2.511). Compared to the lowest quartile, non-HDL-C in the highest quartile was independently associated with a 1.317-fold increased risk of carotid plaques in normotensive and euglycemic Chinese females.
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