Key result
Intermediate-density lipoproteins (IDL) were significantly associated with the progression of carotid artery intima-media thickness (r=0.21, P<0.005), whereas LDL and VLDL were not.
Why the study?
Is intermediate-density lipoprotein (IDL) associated with the progression of carotid artery intima-media thickness in patients with coronary artery disease?
Population
188 subjects aged 37 to 67 years with angiographically defined coronary artery disease
Comparison
Lovastatin 80 mg/d plus cholesterol-lowering diet vs Placebo plus cholesterol-lowering diet
Design
RCT, randomized, double-blind, placebo-controlled
Authors
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May refine lipid risk assessment in CAD; extends focus on IDL beyond LDL in atherosclerosis research.
RCT (n=188)
double-blind
randomized
Is intermediate-density lipoprotein (IDL) associated with the progression of carotid artery intima-media thickness in patients with coronary artery disease?
Effect estimate: r=0.21
p-value: p=<.005
Intermediate-density lipoproteins (IDL), rather than LDL or VLDL, are significantly associated with the progression of carotid artery intima-media thickness, highlighting the atherogenic role of triglyceride-rich lipoproteins.
Hodis et al. (1997) conducted an RCT in angiographically defined coronary artery disease (n=188). lovastatin vs. placebo was evaluated on annual progression rate of the distal common carotid artery far wall intima-media thickness (r=0.21, p=<.005). Intermediate-density lipoproteins (IDL) were significantly associated with the progression of carotid artery intima-media thickness (r=0.21, P<0.005), whereas LDL and VLDL were not.
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