What question did this study set out to answer?

To determine whether carotid arterial intima-media thickness and its rate of progression predict future clinical coronary events.

February 15, 1998Annals of Internal Medicine

The Role of Carotid Arterial Intima-Media Thickness in Predicting Clinical Coronary Events

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Why the study?

Does progression of carotid arterial intima-media thickness predict clinical coronary events in men with prior coronary artery bypass graft surgery?

Population

146 men, 40 to 59 years of age, who had previously had coronary artery bypass graft surgery.

Design

Cohort

Follow-up

average 8.8 years

Authors

HHHoward N. HodisPennington Biomedical Research Center

Discussion

Member takes

Implication

Carotid IMT progression was associated with higher coronary event risk post-CABG; leaves open its validity as a surrogate endpoint.

Key Points

To determine whether carotid arterial intima-media thickness and its rate of progression predict future clinical coronary events.
Conducted an average 8.8-year follow-up of 146 men aged 40 to 59 years with prior coronary artery bypass graft surgery who completed the 2-year randomized Cholesterol Lowering Atherosclerosis Study.
Evaluated common carotid artery intima-media thickness every 6 months using B-mode ultrasonography alongside baseline and 2-year quantitative coronary angiography.
Tracked post-trial coronary endpoints, defined as nonfatal acute myocardial infarction, coronary death, or coronary artery revascularization.
Each 0.03-mm annual increase in carotid intima-media thickness was associated with a relative risk of 2.2 (95% CI, 1.4 to 3.6) for nonfatal myocardial infarction or coronary death, and 3.1 (95% CI, 2.1 to 4.5; P < 0.001) for any coronary event.
Absolute carotid intima-media thickness was significantly associated with coronary event risk (P < 0.02).
Both absolute thickness and thickness progression predicted coronary event risk independently of coronary angiographic measures and lipid levels (P < 0.001).

Structured PICO

Does progression of carotid arterial intima-media thickness predict clinical coronary events in men with prior coronary artery bypass graft surgery?

Population

146 men, 40 to 59 years of age, who had previously had coronary artery bypass graft surgery.

Intervention

Measurement of carotid arterial intima-media thickness progression using B-mode ultrasonography.

Outcome

Incidence of coronary events (composite of nonfatal acute myocardial infarction, coronary death, and coronary artery revascularization).composite

Progression of carotid intima-media thickness strongly predicts future clinical coronary events in men with prior CABG, validating its use as a surrogate endpoint for atherosclerosis progression.

Cite This Study

Howard N. Hodis (1998) studied this question.

synapsesocial.com/papers/6a7ca1860a04747f304c719b https://doi.org/10.7326/0003-4819-128-4-199802150-00002

Topics

Coronary artery disease

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The Role of Carotid Arterial Intima-Media Thickness in Predicting Clinical Coronary Events

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Role of Carotid Arterial Intima-Media Thickness in Predicting Clinical Coronary Events

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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