Key result
Carotid intima media thickness greater than 0.84 mm significantly predicted the presence of coronary artery disease with an odds ratio of 9.8 compared to those with lower thickness.
Why the study?
Does increased carotid intima media thickness predict the presence of angiographically proven coronary artery disease in adults with vascular risk factors?
Case-Control (n=100)
No
Does increased carotid intima media thickness predict the presence of angiographically proven coronary artery disease in adults with vascular risk factors?
Effect estimate: OR 9.8 (95% CI 2.427-45.89)
Absolute Event Rate: 94.2% vs 62.5%
p-value: p=<0.001
Increased carotid intima media thickness is strongly associated with the presence of angiographically proven coronary artery disease, supporting its use as a noninvasive predictor of atherosclerosis.
Carotid intima media thickness is used as a safe, noninvasive, surrogate endpoint to measure severity and progression of generalised atherosclerosis. The basis of almost all cardiovascular diseases is atherosclerosis, which is almost invariably present in all adults. Two vascular beds, coronary artery and carotid artery share same atherosclerosis risk factors and anatomically, first immediate closest branches which originate from aorta, so intima media thickness of carotid artery can be used as golden markers in prediction of atherosclerosis, presence of coronary artery disease and risk of developing disease in later life.
No takes yet. Share an insight, caveat, or question.
Gupta et al. (2016) conducted a case-control in Coronary Artery Disease (n=100). Carotid Intima Media Thickness (IMT) > 0.84 mm vs. IMT < 0.84 mm was evaluated on Presence of Coronary Artery Disease (CAD) (OR 9.8, 95% CI 2.427-45.89, p=<0.001). Carotid intima media thickness greater than 0.84 mm significantly predicted the presence of coronary artery disease with an odds ratio of 9.8 compared to those with lower thickness.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: