Key result
Intradialytic hypotension linked to ~15% lower corrected serum magnesium at the end of dialysis.
Why the study?
The significance of intradialytic changes of serum magnesium and its relation to intradialytic hypotension in hemodialysis patients was unclear.
Is there an association between intradialytic hypotension and serum magnesium changes in patients undergoing hemodialysis?
Observational (n=58)
Is there an association between intradialytic hypotension and serum magnesium changes in patients undergoing hemodialysis?
Absolute Event Rate: 0.61% vs 0.72%
p-value: p=0.03
Intradialytic hypotension is significantly associated with lowered serum magnesium levels during hemodialysis sessions.
Should not yet change magnesium management in hemodialysis; hypothesis-generating for prospective trials on intradialytic hypotension prevention.
Intradialytic hypotension (IDH) is the most common complication of hemodialysis (HD). The aim of this study was to investigate the significance of intradialytic changes of serum magnesium (sMg) and its relation to IDH. We considered 58 patients undergoing HD. Serum magnesium was measured at start, after 2 hours, and at the end of the HD sessions. Total sMg concentration corrected for albumin was according to Krolles proposed formula. Blood pressure was measured every 30 min. Data were analyzed by SPSS.15. A P value of less than 0.05 was considered as significant. Occurrence of IDH among HD patients was 27.6% (16/58). Serum magnesium decreased significantly during HD session (P<0.05). Comparing corrected sMg in IDH group with non-IDH group showed that: corrected sMg was 0.66 ± 0.14 mmol/L vs. 0.84 ± 0.26 mmol/L at the start of dialysis (P=0.43), 0.62 ± 0.17 mmol/L vs. 0.74 ± 0.23 mmol/L (P=0.04) at 2 hours, and 0.61 ± 0.12 mmol/L vs. 0.72 ± 0.22 mmol/L (P=0.03) at the end of dialysis. Intradialytic hypotension episodes were significantly related to a decrease in sMg during dialysis (P=0.02). There was a significant decrease in sMg levels during dialysis. Intradialytic hypotension was significantly related to lowered sMg levels during dialysis.
No takes yet. Share an insight, caveat, or question.
Pakfetrat et al. (2010) conducted an observational in Hemodialysis (n=58). Intradialytic hypotension vs. No intradialytic hypotension was evaluated on Corrected serum magnesium at the end of dialysis (mmol/L) (p=0.03). Intradialytic hypotension was significantly associated with lower corrected serum magnesium levels at the end of dialysis (0.61 vs. 0.72 mmol/L; P=0.03).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: