Key result
Scorpion antivenom or insulin reverses ECG changes and lowers cardiac enzymes in experimental animals.
Why the study?
The effects of species-specific scorpion antivenom and insulin on reversing ECG and cardiac enzyme changes caused by Mesobuthus tamulus concanesis scorpion venom were investigated.
Does species-specific scorpion antivenom or insulin improve electrocardiographic changes and cardiac enzyme levels in experimental animals with scorpion venom-induced acute myocardiopathy?
Does species-specific scorpion antivenom or insulin improve electrocardiographic changes and cardiac enzyme levels in experimental animals with scorpion venom-induced acute myocardiopathy?
Insulin administration provides metabolic support and improves clinical and biochemical parameters in scorpion venom-induced acute myocardiopathy in animal models.
Hypothesis-generating in animal models; leaves open translation to human scorpion envenomation therapy.
Acute myocardiopathy in experimental dogs and rabbits was induced by subcutaneous (SQ) injection of 3.5 mg/kg of scorpion venom from Mesobuthus tamulus concanesis, Pocock. An increase in circulating lactic dehydrogenase (LDH), serum glutamic oxalacetic transaminase (SGOT), creatine kinase-MB isoenzyme (CK-MB), serum glutamine pyrovate transaminase (SGPT) and alpha hydroxy butyrate dehydrogenase (HBDH) enzyme levels was observed in dogs 60 min after venom injection, and a further rise was observed 120 min after venom injection. The administration of the species-specific scorpion antivenom (SAV) at different time intervals after venom injection resulted in reversal of electrocardiographic changes and a reduction in cardiac enzyme levels. The administration of SAV to scorpion envenomed alloxan-pretreated animals did not cause clinical or biochemical improvement. On the other hand, administering insulin to envenomed only animals or envenomed alloxan-pretreated animals resulted in a biochemical and clinical improvement, as well as in a reduction of the cardiac enzyme levels. Insulin administration in scorpion envenoming syndrome is essentially a metabolic support to control the adverse effects triggered by catecholamines and other counter-regulatory hormones.
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Murthy et al. (1999) studied Acute myocardiopathy induced by scorpion venom. Species-specific scorpion antivenom (SAV) and/or insulin was evaluated on Reversal of electrocardiographic changes and reduction in cardiac enzyme levels. Administration of species-specific scorpion antivenom or insulin resulted in reversal of electrocardiographic changes and reduction in cardiac enzyme levels in experimental animals.
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