Enantioselective Total Synthesis and Determination of the Absolute Configuration of the 4,6,8,10,16,18‐Hexamethyldocosane from Antitrogus parvulus

A copper-catalyzed sp3–sp3 cross-coupling for fragment coupling in a total synthesis is demonstrated. The diastereo- and enantioselective total synthesis of the 4,6,8,10,16,18-hexamethyldocosanes highlights the synthetic power of deoxypropionate construction based on an ortho-diphenylphosphanylbenzoyl (o-DPPB)-directed and copper-mediated allylic substitution with Grignard reagents (see scheme).