Key result
Porcine parvovirus 7 was highly prevalent in blood, stool, and saliva samples from pigs in southern China, and its presence was associated with significantly higher viremia levels of PCV2, PCV3, and PRRSV.
Why the study?
Porcine parvovirus 7 (PPV7) was recently identified and its genetic diversity, prevalence, and coinfection patterns in southern China were not well characterized.
Observational (n=1,167)
The study identifies high prevalence and genetic diversity of PPV7 and its coinfection with other porcine viruses in southern China.
PPV7 detection in South China herds warrants expanded surveillance; leaves open its role in reproductive disorders amid coinfections.
Porcine parvovirus (PPV) is the primary cause of reproductive disorders in pigs. The porcine parvovirus 7 (PPV7) subtype was first identified in the United States in 2016. In this study, PPV7 was detected in different porcine samples, including serum, feces, saliva, and milk, from 69 pig farms in the Fujian and Guangdong regions of South China, and its coinfection with porcine circovirus 2 (PCV2), porcine circovirus 3 (PCV3), and porcine reproductive and respiratory syndrome virus (PRRSV) was determined. Whole-genome sequencing, phylogenetic analysis, and recombination analysis were performed on seven isolates, with each selected isolate originating from a different farm. There was a high rate of PPV7 positivity in blood, stool, and saliva but PPV7 DNA was absent from breast milk. The findings also showed that PPV7-positive samples had a high rate of coinfection with PCV2, PCV3, and PRRSV. Real-time PCR was used to determine the viral copy numbers of PCV2, PCV3, PRRSV, and PPV7 in serum samples and to assess whether PPV7 affected PCV2, PCV3, and PRRSV viral loads. Phylogenetic analysis showed that PPV7e and PPV7f were the most prevalent and widespread subtypes in the Fujian and Guangdong regions, respectively. While the PPV7a, PPV7b, PPV7c, and PPV7f subtypes were most prevalent in Fujian Province, PPV7a-e subtypes were prevalent in Guangdong, indicating that PPV7 has rich genetic diversity in these regions. A putative recombinant strain, 21FJ09, was identified using SimPlot and the Recombination Detection Program 4 software.
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Zhang et al. (2022) conducted an observational in Porcine parvovirus 7 (PPV7) infection (n=1,167). Porcine parvovirus 7 (PPV7) infection vs. PPV7-negative samples was evaluated on Prevalence of PPV7 and coinfection viral loads of PCV2, PCV3, and PRRSV. Porcine parvovirus 7 was highly prevalent in blood, stool, and saliva samples from pigs in southern China, and its presence was associated with significantly higher viremia levels of PCV2, PCV3, and PRRSV.
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