Key result
Targeted medical therapy reverses severe DCM and VT from thyroid storm within 48 hours.
Why the study?
Heart failure is the leading cause of mortality in thyroid storm patients, but the underlying cardiac pathology remains unclear.
Case Report (n=1)
Highlights the potential for thyroid storm to present with severe dilated cardiomyopathy and life-threatening arrhythmias such as sustained ventricular tachycardia.
Prompt treatment of thyroid storm may reverse severe cardiomyopathy and VT; this Level 5 case leaves open generalizability.
Thyroid storm is an extreme form of hyperthyroidism associated with a high mortality rate. Heart failure is considered the leading cause of mortality in patients with thyroid storm, though the underlying cardiac pathology is unclear. Approximately 6% of patients with thyroid storm have heart failure symptoms as the initial presenting complaint. Roughly, one-third of these patients develop dilated cardiomyopathy (DCM). In this report, we present a case of cardiogenic pulmonary edema and sustained ventricular tachycardia in a patient with hyperthyroidism presenting with thyroid storm.
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Sourial et al. (2019) conducted a case report in Thyroid storm, severe dilated cardiomyopathy, and ventricular tachycardia (n=1). Medical management (anti-thyroid drugs, beta-blockers, and corticosteroids) was evaluated on Clinical recovery and left ventricular function. A 52-year-old woman with thyroid storm developed severe dilated cardiomyopathy and ventricular tachycardia, which improved dramatically after 48 hours of targeted medical therapy.
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