Key result
miR-Let-7f suppresses glioma vasculogenic mimicry in vitro by targeting periostin-dependent migration.
Why the study?
The molecular mechanisms by which microRNA-Let-7f inhibits vasculogenic mimicry in human glioma cells remain poorly clarified.
p-value: p=<0.01
miR-Let-7f may serve as a potential complementary therapeutic target in the anti-angiogenesis treatment of gliomas by suppressing vasculogenic mimicry.
Should not yet alter glioma anti-angiogenesis practice; leaves open miR-Let-7f as a vasculogenic mimicry target for preclinical validation.
The present study was the first to examine the effect of microRNA-Let-7f (miR-Let-7f) inhibiting vasculogenic mimicry (VM) of human glioma cells. The postoperative survival time was significantly poor in VM-positive glioma patients compared with those without VM. Thus, it is reasonable to postulate that miR-Let-7f functions as a potent tumor suppressor by inhibiting glioma VM. However, the molecular mechanisms involved remain poorly clarified. Our preliminary studies revealed that miR-Let-7f suppressed VM by disturbing periostin (POSTN)-induced migration of glioma cells. Our results clearly demonstrated that inhibiting the pro-migratory function of POSTN by the overexpression of miR-Let-7f significantly reduced the formation of VM. Our findings suggest that miR-Let-7f may serve as a potential complementary therapeutic target in the anti‑angiogenesis treatment of gliomas via suppressing VM.
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Xue et al. (2016) studied Glioma (n=47). miR-Let-7f vs. Scrambled control / VM negative was evaluated on Vasculogenic mimicry (VM) formation and postoperative survival (p=<0.01). Vasculogenic mimicry was associated with poor postoperative survival in glioma patients, and in vitro experiments demonstrated that miR-Let-7f suppresses this mimicry by targeting periostin-dependent migration.
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