What question did this study set out to answer?

To characterize the clinicopathologic features, immunophenotypic profile, and clinical outcomes of T-cell lymphoma primarily localized to the subcutaneous adipose tissue.

January 1, 1991The American Journal of Surgical Pathology

T-Cell Lymphoma Involving Subcutaneous Tissue

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Authors

CGChristopher L. GonzalezUniversity of Alabama at Birmingham LML. Jeffrey MedeirosNorthwestern University RBRita M. BrazielOregon Health & Science University

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Implication

Case series reveals severe hemophagocytic syndrome in subcutaneous T-cell lymphoma, highlighting diagnostic challenges and high mortality.

Key Points

To characterize the clinicopathologic features, immunophenotypic profile, and clinical outcomes of T-cell lymphoma primarily localized to the subcutaneous adipose tissue.
Retrospective case series analyzing eight patients (N=8) presenting with subcutaneous nodules involving adipose tissue.
Conducted histopathological evaluation, paraffin and frozen-section immunophenotyping, and T-cell receptor beta-chain gene rearrangement analysis, alongside clinical follow-up and autopsy examination in deceased patients.
Lesions mimicked panniculitis with atypical lymphoid infiltrates, fat necrosis, and karyorrhexis; 5 of 8 cases were initially referred with an initial benign diagnosis or suggestion.
All 8 patients developed signs of hemophagocytosis, with 6 experiencing a florid hemophagocytic syndrome that proved fatal in 5 cases, while 3 patients survived disease-free following aggressive chemotherapy (mean follow-up of 12 months).

Cite This Study

Gonzalez et al. (1991) studied this question.

synapsesocial.com/papers/6ab09299ed58ea346ce78a0e https://doi.org/10.1097/00000478-199101000-00002

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Implication

Case series reveals severe hemophagocytic syndrome in subcutaneous T-cell lymphoma, highlighting diagnostic challenges and high mortality.

T-Cell Lymphoma Involving Subcutaneous Tissue

Discussion

Member takes

Implication

Key Points

Cite This Study

T-Cell Lymphoma Involving Subcutaneous Tissue

Discussion

Member takes

Implication

Key Points

Cite This Study

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