Global Longitudinal Strain Corrected by RR Interval is a Superior Predictor of All-Cause Mortality in Patients with Systolic Heart Failure and Atrial Fibrillation
Key result
Decreasing RR-corrected GLS is linked to ~16% higher mortality in HFrEF patients with AF.
- HR 1.16
- 95% CI 1.02-1.22
- P=0.014
- n=151
Why the study?
Quantification of systolic function in patients with atrial fibrillation is challenging and the superiority of RR interval-corrected global longitudinal strain in HFrEF patients with AF was unknown.
Does RR interval-corrected global longitudinal strain (GLSc) improve prediction of all-cause mortality compared to uncorrected GLS or LVEF in patients with HFrEF and atrial fibrillation?
Population
151 HFrEF patients with AF during echocardiographic examination
Comparison
RR interval-corrected GLS vs uncorrected GLS and LVEF
Design
Cohort study
Follow-up
Median 2.7 years
Authors
Discussion
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Member takes
Overview
GLSc may refine mortality risk stratification in HFrEF with AF; leaves open its clinical adoption pending prospective validation.
Study Design
Type
Cohort (n=151)
Structured PICO
Does RR interval-corrected global longitudinal strain (GLSc) improve prediction of all-cause mortality compared to uncorrected GLS or LVEF in patients with HFrEF and atrial fibrillation?
P
Population
151 patients with systolic heart failure and atrial fibrillation during echocardiographic examination, followed for a median of 2.7 years.
E
Exposure
RR interval-corrected peak global longitudinal strain (GLSc = GLS/[RR^(1/2)])
C
Comparator
Uncorrected global longitudinal strain (GLS) and left ventricular ejection fraction (LVEF)
O
Outcome
All-cause mortalityhard clinical
Main Result
Hazard Ratio: 1.16 (95% CI 1.02–1.22)
p-value: p=0.014
RR interval-corrected global longitudinal strain (GLSc) is superior to uncorrected GLS and LVEF for predicting all-cause mortality in patients with HFrEF and atrial fibrillation.
Cite This Study
Modin et al. (2017) conducted a cohort in Systolic heart failure and atrial fibrillation (n=151). RR interval-corrected peak global longitudinal strain (GLSc) was evaluated on All-cause mortality (HR 1.16, 95% CI 1.02-1.22, p=0.014). Decreasing RR interval-corrected global longitudinal strain was significantly associated with increased all-cause mortality in HFrEF patients with AF (HR 1.16; 95% CI 1.02-1.22; P=0.014).