Key result
Staged corrective surgery for neonatal pulmonary atresia improves diastolic filling time index by ~45%.
Why the study?
The changes in right ventricular diastolic function in neonates with pulmonary atresia and intact ventricular septum undergoing corrective surgery were not well characterized.
Does corrective surgery improve right ventricular diastolic indices in neonates with pulmonary atresia and intact ventricular septum?
Population
12 neonates with pulmonary atresia and intact ventricular septum and 29 normal babies
Comparison
Pre-intervention vs post-intervention and normal controls
Design
Observational pulsed Doppler echocardiographic study
Authors
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May support diastolic indices as markers of successful palliation in PA/IVS; leaves open effects on long-term outcomes.
Observational (n=41)
Does corrective surgery improve right ventricular diastolic indices in neonates with pulmonary atresia and intact ventricular septum?
Absolute Event Rate: 0.29% vs 0.43%
p-value: p=<0.01
Corrective surgery in neonates with pulmonary atresia and intact ventricular septum normalizes right ventricular diastolic filling patterns when a good surgical result is achieved.
Leung et al. (1991) conducted an observational in Pulmonary atresia and intact ventricular septum (n=41). Pulmonary atresia and corrective surgery vs. Normal babies was evaluated on Index of the time of diastolic filling (T/RR) (p=<0.01). Neonates with pulmonary atresia had a lower diastolic filling time index than normal babies (0.29 vs 0.43, p<0.01), which improved to 0.42 (p<0.001) after successful staged corrective surgery.
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