Key result
CD3+ T lymphocyte susceptibility phenotype is linked to higher risk of becoming EAV carriers.
Why the study?
The correlation between in vitro susceptibility of CD3+ T lymphocytes to EAV infection and the establishment of persistent infection in stallions was unclear.
Does in vitro susceptibility of CD3+ T lymphocytes to EAV infection correlate with the establishment of persistent infection in naturally infected stallions?
Observational (n=14)
Does in vitro susceptibility of CD3+ T lymphocytes to EAV infection correlate with the establishment of persistent infection in naturally infected stallions?
p-value: p=0.0002
In vitro susceptibility of CD3+ T lymphocytes to EAV infection correlates with the risk of stallions becoming carriers after natural infection.
May aid identification of EAV carrier risk in stallions; hypothesis-generating for CD3+ T-cell phenotyping and requires prospective validation.
We investigated the correlation between in vitro susceptibility of CD3(+) T lymphocytes to equine arteritis virus (EAV) infection and establishment of persistent infection among 14 stallions following natural infections. The data showed that carrier stallions with a CD3(+) T lymphocyte susceptibility phenotype to in vitro EAV infection may be at higher risk of becoming carriers than those that lack this phenotype (P = 0.0002).
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Go et al. (2012) conducted an observational in Equine arteritis virus (EAV) infection (n=14). CD3(+) T lymphocyte susceptibility phenotype to in vitro EAV infection vs. Lack of CD3(+) T lymphocyte susceptibility phenotype was evaluated on Establishment of persistent infection (becoming carriers) (p=0.0002). Stallions with a CD3(+) T lymphocyte susceptibility phenotype to in vitro EAV infection were at higher risk of becoming carriers following natural infection (P = 0.0002).
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