Key result
Nine MyHC isoforms populate dog rectus muscles with distinct coexpression across global and orbital layers.
Why the study?
Myosin heavy chain isoform expression patterns in dog rectus muscles, including differences between global and orbital layers and among single fibers, were not fully characterized.
Population
Dog rectus muscles global and orbital layers
Comparison
MyHC and MLC isoform patterns between global and orbital layers and among single fibers
Design
Gel electrophoresis and single fiber analysis study
Authors
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EOM MyHC heterogeneity in dogs is hypothesis-generating; human oculomotor studies needed before clinical relevance.
Bicer et al. (2009) studied this question. Myosin isoform expression analysis was evaluated on Distribution of myosin heavy chain (MyHC) and myosin light chain (MLC) isoforms. Nine MyHC isoforms were detected in dog rectus muscles, with marked gradients and complex coexpression patterns differing between global and orbital layers.
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