Key result
Achalasia patient serum alters myenteric plexus neurochemical coding and impairs nitrergic responses to nerve stimulation.
Why the study?
New insights into achalasia pathogenesis indicate that serum from patients with achalasia alters neurochemical coding and impairs nitrergic response in the myenteric plexus.
Serum from achalasia patients impairs nitrergic relaxation in the myenteric plexus, suggesting a humoral component in its pathogenesis.
Implicates humoral factors in achalasia pathogenesis; leaves open therapeutic relevance pending validation.
New insights into the pathogenesis of achalasia indicate that incubation with serum from patients with achalasia leads to altered neurochemical coding of the myenteric plexus and impairs the nitrergic response to nerve stimulation
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Guy E. Boeckxstaens (2006) studied this question. Incubation with serum from patients with achalasia alters neurochemical coding of the myenteric plexus and impairs the nitrergic response to nerve stimulation.
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