Why the study?
Are functional polymorphisms in the nNOS, iNOS, or eNOS genes associated with susceptibility to sporadic achalasia?
Population
80 unrelated Spanish Caucasian patients with sporadic achalasia and 144 healthy subjects matched for age and…
Comparison
Presence of functional polymorphisms in the… vs Healthy subjects matched for age and gender
Design
Case-control
Authors
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No association of NOS polymorphisms with achalasia susceptibility; leaves open other genetic or environmental contributors in sporadic disease.
Are functional polymorphisms in the nNOS, iNOS, or eNOS genes associated with susceptibility to sporadic achalasia?
NOS gene polymorphisms do not appear to be significantly associated with susceptibility to sporadic achalasia in a Spanish Caucasian population, though non-significant trends were observed for certain genotypes.
Mearin et al. (2006) studied this question.
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