Key result
Left atrial reservoir strain ≤14.4% is linked to ~237% higher risk of NOAF.
Why the study?
The ability of left atrial reservoir strain (LASr) to predict new-onset atrial fibrillation (NOAF) in patients with light-chain-type cardiac amyloidosis (ALCA) was unclear.
Does left atrial reservoir strain predict new-onset atrial fibrillation in patients with light-chain-type cardiac amyloidosis?
Population
287 patients with ALCA from two tertiary centres
Comparison
LASr ≤14.4% vs LASr >14.4%
Design
Cohort study
Follow-up
Median 0.85 years
Authors
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May inform AF surveillance in light-chain amyloidosis; extends strain prognostication but remains hypothesis-generating.
Cohort (n=287)
Yes
Does left atrial reservoir strain predict new-onset atrial fibrillation in patients with light-chain-type cardiac amyloidosis?
Hazard Ratio: 3.37 (95% CI 1.337–8.492)
Absolute Event Rate: 18.1% vs 5.1%
p-value: p=0.010
Left atrial reservoir strain is an independent predictor of new-onset atrial fibrillation in patients with light-chain cardiac amyloidosis, offering incremental prognostic value over left ventricular global longitudinal strain and left atrial volume index.
Choi et al. (2023) conducted a cohort in light-chain-type cardiac amyloidosis (ALCA) (n=287). Left atrial reservoir strain (LASr) ≤14.4% vs. LASr >14.4% was evaluated on new-onset atrial fibrillation (NOAF) (aHR 3.370, 95% CI 1.337-8.492, p=0.010). Left atrial reservoir strain ≤14.4% was independently associated with a higher risk of new-onset atrial fibrillation compared to >14.4% (18.1% vs 5.1%; aHR 3.370, 95% CI 1.337-8.492, P=0.010).
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