Key result
Higher early WBC count correlates with lower LVEF in STEMI patients.
Why the study?
Elevated WBC count in acute myocardial infarction has been linked to adverse outcomes, but its relationship with ejection fraction in STEMI patients within 24 hours of symptom onset was unclear.
Does early WBC count correlate with ejection fraction in patients presenting with STEMI?
Cohort (n=49)
Does early WBC count correlate with ejection fraction in patients presenting with STEMI?
Effect estimate: Pearson Correlation = -0.462
p-value: p=0.001
Early white blood cell count is significantly and inversely correlated with ejection fraction in STEMI patients, suggesting its potential utility as a simple, accessible prognostic marker for cardiac dysfunction.
Early WBC elevation was associated with lower EF in STEMI; hypothesis-generating and requires prospective validation before clinical use.
Background: Elevated White Blood Cell Count (WBC-C) in the setting of acute myocardial infarction (AMI) has been linked to adverse cardiovascular outcomes. This study explores the relationship between WBC-C within the first 24 hours of chest pain onset and ejection fraction in ST-segment elevation myocardial infarction (STEMI) patients. Methods: A cohort of 49 STEMI patients presenting within 24 hours of symptom onset was enrolled. WBC count and ejection fraction were assessed immediately upon admission. Upon presentation, the white blood cell (WBC) count was promptly assessed using standard laboratory techniques. Simultaneously, echocardiography was performed to measure the ejection fraction, providing an immediate snapshot of cardiac function.Statistical analyses evaluated the correlation between ejection fraction and WBC count. Results: The cohort demonstrated diverse age distribution, with the majority falling within the 41-60-year range. Males constituted the majority with 35 participants (71.4%), while females accounted for 14 participants (28.6%). Ejection fraction varied across three categories: <40%, 41-50%, and 51-60%. Anterior Wall Myocardial Infarction (AWMI) was identified in 53.1%, while 46.9% presented with Inferior Wall Myocardial Infarction (IWMI). A significant negative correlation emerged between ejection fraction and WBC count (Pearson Correlation = -0.462, p-value = 0.001). Conclusion: This study uncovers a significant link between early WBC count and ejection fraction in STEMI patients. Lower ejection fractions align with higher WBC counts, indicating heightened inflammation. These findings inform risk assessment and tailored treatments. Further research is needed for broader clinical application and mechanistic insights.
No takes yet. Share an insight, caveat, or question.
Hussain et al. (2023) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=49). Early White Blood Cell (WBC) count was evaluated on Correlation between ejection fraction and WBC count (Pearson Correlation = -0.462, p=0.001). Early white blood cell count within 24 hours of chest pain onset in STEMI patients showed a significant negative correlation with ejection fraction (Pearson r = -0.462, p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: