Key result
Childhood metabolically healthy obesity links to ~188% greater risk of health disorders versus normal weight.
Why the study?
Research specifically examining health disorders risks in children with metabolically healthy obesity (MHO) remains limited despite its emerging recognition as a distinct obesity phenotype.
Does metabolically healthy obesity increase the risk of health disorders compared to normal weight in children?
Meta-Analysis (n=19,119)
Does metabolically healthy obesity increase the risk of health disorders compared to normal weight in children?
Odds Ratio: 2.88 (95% CI 1.64–5.06)
Children with metabolically healthy obesity remain at a significantly increased risk for health disorders, including left ventricular hypertrophy and hypertension, compared to normal-weight peers.
Pediatric MHO warrants closer cardiometabolic monitoring; confirms obesity confers excess risk even without overt metabolic abnormalities.
Background and Objectives: Childhood obesity is associated with both short-term and long-term health complications, yet a new obesity phenotype called metabolically healthy obesity (MHO) has emerged. While MHO is often perceived as a "benign" form of obesity, research specifically examining health disorders risks in children with MHO remains limited. This systematic review and meta-analysis aimed to evaluate health disorders in children with MHO. Methods: Following PRISMA 2020 guidelines, we systematically searched five databases (PubMed, Scopus, Google Scholar, EBSCO, and ScienceDirect) for observational studies examining MHO children aged 0-18 years. The studies were analyzed using R and R Studio software, with study quality assessed using the Newcastle Ottawa Scale. Results: Ten studies with a total of 19,119 children were included in this review. Children with MHO demonstrated significantly higher overall health disorders risk compared to MHNW children (pooled OR 2.88, 95% CI [1.64; 5.06]). This trend aligns with the subgroups analysis of left ventricle hypertrophy, hypertension, and kidney damage. However, some of the subgroup analyses showed insignificant results. Additionally, MHO children showed lower risks of experiencing health disorders compared to MUO children (pooled OR 0.56, 95% CI [0.23; 1.34]). The underlying mechanism of the increased health risk is excess adipokines causing systemic inflammation and leading to increased various health risks. Conclusion: Despite metabolically "healthy" status, children with MHO remain at increased risk for health disorders compared to normal-weight peers. This systematic review and meta-analysis is the first one discussing the health disorders in children with MHO. More studies are required in the future to reinforce these findings in order to produce much more comprehensive insights.
No takes yet. Share an insight, caveat, or question.
Suhamdy et al. (2025) conducted a meta-analysis in Metabolically healthy obesity (n=19,119). Metabolically healthy obesity vs. Metabolically healthy normal weight was evaluated on Overall health disorders risk (OR 2.88, 95% CI 1.64-5.06). Children with metabolically healthy obesity demonstrated a significantly higher overall risk of health disorders compared to metabolically healthy normal weight children (OR 2.88).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: